Why is acetic anhydride used instead of acetic acid in the synthesis of aspirin

Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid. Use: Used for the relief of minor pains/aches and also mild to moderate pain. It is recommended for arthritis and related arthritic conditions, myocardial...Synthesis of Aspirin in Organic ChemistryFull description... Acetic anhydride also known as ethanoic anhydride or methyl carboxylic anhydride is a colourless liquid, very similar to acetic acid in its pungent, acrid odour, viscosity, density & refract…Full description

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For the synthesis of acetylsalicylic acid from salicylic, acid acetic anhydride is usually used as an acetylating agent.The increased reactivity of acetyl chloride is basically not needed here. Due to problems in the acquisition of acetic anhydride it is at a minimum of interest to hobby chemists.

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Mar 22, 2010 · Acetic anhydride reacts with salicylic acid to form aspirin. The sulfuric acid speeds the reaction so it happens in seconds instead of hours or days. Concentrated acid must be used because we want to remove water, so we do not want to add any water.


If unreacted amine is still present after the second coupling, acetic anhydride should be used to cap it. Capping prevents deletion peptide impurities from forming by blocking any further reactions at the unreacted sites. Capping can also make purification of the crude peptide product easier. The used of acetic anhydride instead of acetic acid as an acetylating agent in this synthesis was one of the relevant point in this experiment because the speed of reaction between salicylic acid and acetic anhydride is faster compared to the reaction between acetic acid and salicylic acid also the used of acetic anhydride in the synthesis ...

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